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61.
62.
Pregnancy by Assisted Reproductive Technology Is Associated with Shorter Telomere Length in Neonates
Toshiko Minamoto Kentaro Nakayama Tomoka Ishibashi Masako Ishikawa Kohei Nakamura Hitomi Yamashita Kamrunnahar Shanta Hossain Mohammad Mahmud Sultana Razia Kouji Iida Gyosuke Sakashita Tsukasa Nakamura Hideyuki Kanda Satoru Kyo 《International journal of molecular sciences》2020,21(24)
Telomere length (TL) influences the development of lifestyle-related diseases, and neonatal TL may influence their prevalence. Various factors have been reported to affect neonatal TL. Although the fetus is exposed to multiple conditions in utero, the main factors affecting the shortening of neonatal TL are still not known. In this study, we sought to identify factors that influence fetal TL. A total of 578 mother-newborn pairs were included for TL analysis. TL was measured in genomic DNA extracted from cord blood samples using quantitative PCR. The clinical factors examined at enrollment included the following intrauterine environmental factors: maternal age, assisted reproductive technology (ART) used, body mass index (BMI), gestational diabetes mellitus (GDM), maternal stress, smoking, alcohol consumption, preterm delivery, small-for-gestational-age, neonatal sex, and placental weight. Univariate and multivariate regression analyses were used to verify the relationship between neonatal TL and these clinical factors. The median neonatal TL to single-copy gene ratio was 1.0. Pregnancy with ART was among the 11 factors associated with shorter neonatal TL. From multiple regression analysis, we determined that neonatal TL was significantly shorter for pregnancies in the ART group than in the other groups. We conclude that pregnancy with ART is associated with shorter neonatal TL. 相似文献
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随着社会经济的发展,如何合理、有序、经济、环保地处理弃土弃渣已成为强降雨地区土石方项目亟需解决的问题。而对于雨林地区土石方工程往往需要布设大面积的排土场进行弃土弃渣,弃土弃渣存在“量大、集中”等特点。为保证弃土有效容量,排土场往往设置在沟谷中,雨林地区排土场如何保证地基处理、渗流层施工、分层填筑碾压是坝体施工质量控制的关键所在。以厄瓜多尔米拉多铜矿采矿工业场地工程项目为例,该项目存在土石方开挖工程量大,项目面临雨季长、高雨频等突出气候特点。项目排土场设计为碾压堆石坝,坝体整体高度84.8 m,坝体填筑石方达27.8万m3。简要介绍了该工程1 095 m排土场坝体施工的特点和难点,叙述坝体施工过程中采取的主要关键技术,为类似的工程施工提供借鉴。 相似文献
66.
Rehena Nasrin Saddam Hossain Ishrat Zahan Khandker Farid Uddin Ahmed Hussain Fayaz 《亚洲传热研究》2020,49(8):4204-4225
This numerical study reveals the heat transfer performance of hybrid/single nanofluids inside a lid-driven sinusoidal trapezoidal-shaped enclosure. The right and left inclined surfaces of the trapezium have been considered as insulated, whereas the bottom sinusoidal wavy and the flat top surfaces of the enclosure as hot and cold, respectively. The governing partial differential equations of fluid's velocity and temperature have been resolved by applying the finite element method. The implications of Prandtl number (4.2-6.2), Richardson number (0.1-10.0), undulation number (0-3), nanoparticles volume fraction (0%-3%), and nanofluid/base fluid (water, water–copper (Cu), water–Cu–carbon nanotube, water–Cu–copper oxide (CuO), water–Cu–TiO2, and water–Cu–Al2O3) on the velocity and temperature profiles have been studied. Simulated findings have been represented by means of streamlines, isothermal lines, and average Nusselt number of above-mentioned hybrid nanofluids for varying the governing parameters. The comparison of heat transfer rates using hybrid nanofluids and pure water has been also shown. The heat transfer rate is increased about 15% for varying Richardson number from 0.1 to 10.0. Blending of two nanoparticles suspension in base fluid has a higher heat transfer rate—approximately 5% than a mononanoparticle. Moreover, a higher average Nusselt number is obtained by 14.7% using the wavy surface than the flat surface of the enclosure. Thus, this study showed that applying hybrid nanofluid may be beneficial to obtain expected thermal performance. 相似文献
67.
溜井测量具有一定的隐蔽性和不确定性,测量时有相当的危险性,如何对溜井的空间形态特征和冒落状况等进行量化评判,是所有矿山面临的难题。本文介绍了三维激光扫描技术的作业流程,给出了点云数据处理的过程和方法,并以安徽开发矿业有限公司3#主溜井测量为例进行数据采集和处理分析,建立了主溜井的三维立体模型,计算得到了主溜井需要修复的体积,为溜井的安全治理和维修设计提供了可靠的数据依据。实践结果表明了三维激光扫描技术在溜井测量中应用的可行性和优越性。 相似文献
68.
Chengyong Yang Bolong Huang Shuxing Bai Yonggang Feng Qi Shao Xiaoqing Huang 《Advanced materials (Deerfield Beach, Fla.)》2020,32(24):2001267
Electrocatalytic nitrogen reduction reaction (NRR) is a promising process relative to energy-intensive Haber–Bosch process. While conventional electrocatalysts underperform with sluggish paths, achieving dissociation of N2 brings the key challenge for enhancing NRR. This study proposes an effective surface chalcogenation strategy to improve the NRR performance of pristine metal nanocrystals (NCs). Surprisingly, the NH3 yield and Faraday efficiency (FE) (175.6 ± 23.6 mg h–1 g–1Rh and 13.3 ± 0.4%) of Rh-Se NCs is significantly enhanced by 16 and 15 times, respectively. Detailed investigations show that the superior activity and high FE are attributed to the effect of surface chalcogenation, which not only can decrease the apparent activation energy, but also inhibit the occurrence of the hydrogen evolution reaction (HER) process. Theoretical calculations reveal that the strong interface strain effect within core@shell system induces a critical redox inversion, resulting in a rather low valence state of Rh and Se surface sites. Such strong correlation indicates an efficient electron-transfer minimizing NRR barrier. Significantly, the surface chalcogenation strategy is general, which can extend to create other NRR metal electrocatalysts with enhanced performance. This strategy open a new avenue for future NH3 production for breakthrough in the bottleneck of NRR. 相似文献
69.
This essay provides a very brief overview of Confucian ethics that focuses on the role-based morality. It compares Confucian ethics with two dominant schools of thought in Western ethics deontology and consequentialism. This essay then discusses how Confucian ethics provides a unique way to think about social and political issues such as how the political leaders are selected and evaluated, the ethical justification of political legitimacy, the prioritization of economic, social, and cultural rights over other rights, and moral egalitarianism. Finally, this essay explores the ways in which Confucian ethics serves as a useful intellectual resource for examining the issues arising from the ethical assessment of (emerging) technologies and the professional formation of engineers. The Appendix of this essay includes some teaching resources that instructors can employ to teach students about ethics, society, and technology from a Confucian role ethics perspective. 相似文献
70.
随着医疗服务体系的发展和进步,越来越多的医院开始将云计算技术引入信息服务系统,使医院信息化建设得到了迅速发展。文章分析了云计算技术的特点及其在智能医院信息服务中的应用和影响,以期促进该技术在未来的发展和推广。 相似文献